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商品編號


30123640



品牌


IBL



公司


IBL,inc



公司分類


Immunology / Cytokines


商品信息

Quantity / Tests
100 ?g
Species / Antigen
Human IgA1 hinge region peptide with GalNAc
Host
Rat
Subclass / Clone
IgG
Type
Polyclonal
Purification
Protein A
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-human Gd-IgA1 (KM55) Rat IgG

"Original article #10777
Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attentions as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in recent studies. It has been suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecule andGd-IgA1 circulates in the blood stream of patients with the pathological condition of IgAN. The deposition of Gd-IgA1 in glomeruli is considered to be involved in IgAN (Multi-hit Hypothesis of Gd-IgA1). The measuring system using snail (Helix aspersa; HAA) lectin that is extracted from snail and Gd-IgA1
ELISA
(Code: 27600 Gd-IgA1 (Galactose-deficient IgA1) Assay Kit using this antibody (KM55) have been used in numerous studies and it has been suggested that serum levels of Gd-IgA1 in patients with IgAN is significantly elevated compared to the levels of healthy subjects or patients with renal disease other than IgAN in such studies. In addition, this antibody (KM55) can detect Gd-IgA1 in tissue by IHC technique differently from the feature of HAA lectin and it has been revealed that Gd-IgA1 specicillay exists in glomeruli of the patients of IgAN from the studies using this antibody. It has been expected that clinical significance of Gd-IgA1 wil be revealed by further studies using this antibody."

For concrete data please consult the Instruction for Use in the download box on the right side.