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商品編號


AG-40B-0029-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

MultimericOX40L?; ACRP30
headless
:OX40L; ACRP30
headless
:CD252; ACRP30
headless
:CD134L



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of mouse OX40L (aa 52-199) is fused at the N-terminus to mouse ACRP30
headless
(aa 18-111) and a FLAG
?
-tag.



Crossreactivity

Human
Mouse



Specificity

Binds to human and mouse OX40 [CD134].



BIOLOG
ical Activity

Activates T cell proliferation.



MW

~40kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.01EU/μg purified protein (LAL test;
Lonza
).



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data


UniProt link P43488: OX40L (mouse)

FLAG is a registered trademark of
Sigma-Aldrich
Co.




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





OX40L [CD252; CD134L] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium.
Multimeric
OX40L is a high activity construct in which two trimeric OX40L ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively activates T cell proliferation.


Product References

Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by st
ABI
lization of cytokine mRNA: J. Mestas, et al.; Int. Immun.
17,
737 (2005)