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商品編號


AG-40T-0013-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Poly(ADP-ribose) Polymerase 3; ADP-ribosyltransferase Diphtheria Toxin-like 3; NAD(+) ADP-ribosyltransferase 3



Product Type

Protein



Properties



Source/Host

Sf21 cells



Sequence

Human full-length PARP-3 [ARTD3] is fused to a HA-tag and a His-tag.



Crossreactivity

Human



BIOLOG
ical Activity

≥10U/mg protein (only monoADP-ribosyl transferase activity).



Purity

≥98% (SDS-PAGE)



Concentration

Lot dependent (0.2-1mg/ml)



Formulation

Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.



Other Product Data

UniProt ID Q9Y6F1: PARP-3 (human)



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

After opening, prepare aliquots and store at -80°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -80°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway le
ADI
ng to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.