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商品編號


AG-40A-0188Y-C010



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Proepithelin; PEPI; PC Cell-derived Growth Factor



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.



Crossreactivity

Human



BIOLOG
ical Activity

Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).



MW

~74kDa (glycosylated protein by SDS-PAGE)



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

After reconstitution:
for 10?g size:
0.1mg/ml
for 50?g size:
1 mg/ml



Reconstitution


10?g size:
Reconstitute with 100?l sterile water.
50?g size:
Reconstitute with 50?l sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data


Uniprot link P28799: Granulins (human) [Precursor]




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tum
Origen
esis. Progranulin is a bio
Marker
for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.? EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.


Product References

Involvement of Progranulin in Hypothalamic Glucose Sensing and Feeding Regulation: H.K. Kim, et al.; Endocrinology
152,
4672 (2011)

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains: J. Jian, et al.; FEBS Lett.
587,
3428 (2013)

Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor B (RANK)-dependent formation of multinucleated osteoclasts: J. Oh, et al.; J. Biol. Chem.
290,
2042 (2015)

New discovery rarely runs smooth: an update on progranulin/TNFR interactions: B.C. Wang, et al.; Protein Cell
6,
792 (2015)

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes: Y. Tanaka, et al.; Hum. Mol. Genet. ahead of print 2017