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商品編號(hào)


CHI-HF-211T4-C100



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4; T Cell Membrane Protein 4



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a.



Crossreactivity

Human



BIOLOG
ical Activity

Measured by its
ABI
lity to inhibit anti-CD3-induced proliferation of stimulated human T cells.



MW

~80kDa (SDS-PAGE)



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<5eu g="" protein="" (lal="" test;="" lonza).="">5eu>



Reconstitution

Reconstitute with 100 ?l sterile water. Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI reference NP_612388.2: Tim-4 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.


Product References

TIM-4 is the ligand for TIM-1, and the TIM-1–TIM-4 interaction regulates T cell proliferation: J. Hartt Meyers, et al.; J. Immunol.
6,
455 (2005)

Tim-4 expressed on antigen-presenting cells induces T cell expansion and survival: R. Rodriguez-Manzanet, et al.; J. Immunol.
180,
4706 (2008)