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商品編號(hào)


CHI-MF-110T4-C100



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of mouse IgG2a.



Crossreactivity

Mouse



BIOLOG
ical Activity

Measured by its
ABI
lity to inhibit anti-CD3-induced proliferation of stimulated human T cells.



MW

~85kDa (SDS-PAGE)



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<5eu g="" protein="" (lal="" test;="" lonza).="">5eu>



Reconstitution

Reconstitute with 100 ?l sterile water. Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI reference NP_848874.3: Tim-4 (mouse)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Mouse T cell immunoglobulin and mucin domain-containing protein 4, also known as T cell membrane protein 4, TIMD4 and TIM4 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their
ABI
lity to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells and may also be involved in intercellular signaling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.