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商品編號


AG-40B-0074-C050



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

p55; CD120a; TNFRSF 1A; Tumor Necrosis Factor Receptor Superfamily Member 1A; TNF Receptor 1



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1.



Crossreactivity

Human
Mouse



Specificity

Binds human and mouse TNF-α.



BIOLOG
ical Activity

TNF-R1:Fc fusion protein blocks TNF-α-mediated
BIOLOG
ical effect with an inhibitory activity in a concentration range of 0.1 to 1μg/ml.



MW

~60kDa (reducing SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

1mg/ml after reconstitution.



Reconstitution

Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link P19438: TNF-R1 (human) (precursor)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





TNF-R1 is a receptor for TNF-α and homotrimeric lymphotoxin-α. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.