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商品編號


AG-40T-0549-C100



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

UBE2N/UBE2V2 Complex



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human Ubc13/UBE2V2 Complex (Accession Nr. Ubc13 | UBE2V2 ) fused to a N-terminal His-tag.



Crossreactivity

Human



MW

~18kDa (Ubc13), ~17kDa (UBE2V2)



Purity

≥95% (SDS-PAGE)



Formulation

Liquid. In 50mM HEPES pH7.5, 200mM NaCl, 10% Glycerol (v/v), 2mM TCEP.



Other Product Data


Use:
Member of the ubiquitin?conjugating (E2) enzyme family that receives ubiquitin from a ubiquitin?activating (E1) enzyme and subsequently interacts with a ubiquitin ligase (E3) to conjugate ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-?1μM.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin?conjugating Enzyme E2N (UBE2N), also known as ubiquitin?conjugating enzyme 13 (Ubc13), forms a functional complex with the catalytically inactive UBE2V2 (human homologue of yeast MMS2) protein. Human UBE2N/Ubc13 shares 100% and 99% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively, while human UBE2V2 shares 99% aa sequence identity with its mouse and rat orthologs. The UBE2N/UBE2V2 Complex functions with ubiquitin ligases (E3s), including RNF111 and RNF8, to synthesize Lys63?linked ubiquitin chains that can either be unanchored or attached to target proteins. The UBE2N/UBE2V2 complex has important roles in facilitating responses to various forms of DNA damage.