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商品編號


AG-40T-0445-C100



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin-conjugating Enzyme E2 T; HSPC150; PIG50; Cell Proliferation-inducing Gene 50 Protein; Ubiquitin-protein Ligase T



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human UBE2T (Accession Nr. EAW91415.1) fused to a N-terminal His-tag.



Crossreactivity

Human



Formulation

Liquid. In 50mM HEPES pH 7.0, 200mM NaCl, 10% Glycerol (v/v), 1mM TCEP.



Other Product Data


Use:
Member of the ubiquitin?conjugating (E2) enzyme family that receives ubiquitin from a ubiquitin?activating (E1) enzyme and subsequently interacts with a ubiquitin ligase (E3) to conjugate ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-?1μM.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin-conjugating Enzyme E2T (UBE2T), also known as HSPC150 protein similar to ubiquitin-conjugating enzyme, is a member of the ubiquitin-conjugating (E2) enzyme family. UBE2T has a predicted molecular weight of 22.5 kDa. The human protein shares 83% and 80% amino acid sequence identity with the mouse and rat orthologs, respectively. UBE2T has an E2 catalytic core domain with an active site cysteine residue and undergoes auto-ubiquitination on Lys91 and either Lys182 or Lys191. UBE2T localizes to the nucleus and nucleolus and plays an important role in the Fanconi anemia DNA repair pathway. More specifically, UBE2T interacts with the RING domain of FANCL to mediate the ubiquitination of FANCD2 on Lys563 following exposure to mitomycin C. UBE2T has also been linked to the nucleotide excision repair pathway in chicken DT40 cells. UBE2T expression is downregulated under hypoxic conditions and it may play a role in the development and/or progression of breast cancer.