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商品編號


SBB-PS0034-C050



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human ubiquitin (aa1-76) (Accession Nr. P0CG47) with a C-terminal propargylamide group.



Crossreactivity

Human



Application

Typical working concentration range is 1-5 μM. Reaction conditions will need to be optimized for each specific application.



MW

~9kDa



Purity

≥97% (LCMS)



Concentration

Lot dependent.



Accession Number

P0CG47



Formulation

Liquid. In 50mM MES pH 6.0, 100mM sodium chloride.



Other Product Data

Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by South Bay Bio.



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity and promote or prevent protein interactions. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various linkage specificities. This product consists of a full-length human, mature ubiquitin polypeptide (amino acids 1-76), expressed in E.coli with a C-terminal warhead (Propargylamide). Ubiquitin propargylamide is a potent, irrevers
IBL
e and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic propargylamide group. Ubiquitin propargylamide can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets three of the four major DUB families: UCH (Ubiquitin C-terminal hydrolases),
USP
(Ubiquitin specific proteases), OTU (Ovarian tumor proteases) and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited.