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商品編號(hào)


AG-40T-0538-C050



品牌


Adipogen



公司


Adipogen



公司分類


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin C-terminal Hydrolase 2; Ubiquitin-specific Protease 2; UBP41;
USP
9; Deubiquitinating Enzyme 2



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human
USP
2 (catalytic domain aa 259-605) (Accession Nr. O75604).



Crossreactivity

Human



MW

~42kDa



Purity

≥95% (SDS-PAGE)



Formulation

Liquid. In 50mM HEPES pH8.0, 200mM NaCl, 0.1mM EDTA and 1mM DTT.



Other Product Data


Use:
Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 1-5nM depending on conditions and substrate.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin Specific Peptidase 2 (
USP
2), also known as UBP41 and
USP
9, is a cytoplasmic protein that belongs to the peptidase C19 family of deubiquitinating enzymes. It is widely expressed and serves to deubiquitinate select target substrates. At least three isoforms have thus far been described:
USP
2a, also known as
USP
2-69,
USP
-41, and
USP
2-45. All isoforms contain the same catalytic core, but show variations within their N- and C-terminal domains.
USP
2a is the canonical isoform. It is 605 amino acids (aa) in length and has a predicted molecular weight of 68 kDa. Human
USP
2a shares 90% aa sequence identity with the mouse and rat orthologs.
USP
-41 and
USP
-45 are 362 and 396 aa in length, respectively and have predicted molecular weights of 41 and 45 kDa.
USP
-41 and
USP
2a have been shown to be critical regulators of cancer and cell proliferation. They deubiquitinate poly-ubiquitinated target proteins, such as FAS, MDM2, and Cyclin D1, to promote or block cancer, depending on the context.
USP
-45, whose expression appears to be regulated by circ
ADI
an and nutritional cues, is thought to regulate hepatic gluconeogenesis and glucose metabolism.