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商品編號


4858/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

50 mg

商品信息

Description:
Selective UBE2N inhibitor

Chemical Name:
2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-
κ
B activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth
in vivo
.



Compound Libraries

NSC 697923 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

267.26



Formula

C
11
H
9
NO
5
S



Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

343351-67-7



PubChem ID

394449



InChI Key

GAUHIPWCDXOLCZ-UHFFFAOYSA-N



Smiles

CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

26.73

100



ethanol

6.68

25mM with gentle warming





Preparing Stock Solutions

The following data is based on the
product
molecular weight
267.26
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.74 mL

18.71 mL

37.42 mL



5 mM

0.75 mL

3.74 mL

7.48 mL



10 mM

0.37 mL

1.87 mL

3.74 mL



50 mM

0.07 mL

0.37 mL

0.75 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Pulvino

et al
(2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood
120
1668 PMID: 22791293


Cheng

et al
(2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis.
5
e1079 PMID: 24556694




Keywords: NSC 697923, supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Post-translational, Modifications, Ubiquitin/Ubl, E2, Conjugating, Enzymes, Ubiquitin/Ubl, E2, Conjugating, Enzymes,
Tocris
Bioscience