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商品編號


5311/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

10 mg

商品信息

Description:
Telomerase inhibitor

Chemical Name:
3,11-Difluoro-6,8,13-trimethylquino[4,3,2-
kl
]acridinium methylsulfate

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells
in vitro
. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice.



Technical Data



M. Wt

458.48



Formula

C
22
H
17
F
2
N
2
.CH
3
O
4
S



Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

390362-78-4



PubChem ID

9804187



InChI Key

VRWGYMXWYZBBGF-UHFFFAOYSA-M



Smiles

C[N+]4=C2C3=C(C=C(C)C=C3C5=C4C=CC(F)=C5)N(C)C1=CC=C(F)C=C12.COS(=O)([O-])=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

9.17

20



water

4.58

10mM with gentle warming





Preparing Stock Solutions

The following data is based on the
product
molecular weight
458.48
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.18 mL

10.91 mL

21.81 mL



5 mM

0.44 mL

2.18 mL

4.36 mL



10 mM

0.22 mL

1.09 mL

2.18 mL



50 mM

0.04 mL

0.22 mL

0.44 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Lagah

et al
(2014) RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One
9
e86187 PMID: 24454961


Salvati

et al
(2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest.
117
3236 PMID: 17932567


Phatak

et al
(2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth
in vitro
and
in vivo
consistent with a cancer stem cell targeting mechanism. Br.J.Cancer
96
1223 PMID: 17406367




Keywords: RHPS 4 methosulfate, supplier, RHPS4, methosulfate, telomerase, inhibitors, inhibits, cancer, telomere, Telomerase, Telomerase,
Tocris
Bioscience